Bob and Margaret is an adult animated sitcom created by David Fine and Alison Snowden and co-produced by Nelvana Limited and Channel 4 as a collaboration, both financial and artistic. The last two seasons were co-produced without Channel 4 but with continuing British involvement in the animation, cast, and screenwriting. The series was based on the Academy Award-winning short film Bob's Birthday, featuring the same main characters, which won the Best Animated Short Film Oscar in 1994. In Canada, it was the highest-rated Canadian-made animated series ever when it aired in primetime on Global.

The show revolves around a married English couple named Bob and Margaret Fish. They are a middle-class professional working couple of forty-ish with no children and two dogs named William and Elizabeth, who often serve as surrogates for children and are considered to be characters with personalities in their own right. Bob is a dentist and Margaret is a chiropodist.